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Study Information

dbGaP Study Accession: phs002600

NIH Institute/Center: NCATS

RADx Data Program: RADx-rad

Release Date: 08/02/2022

DOI: 10.60773/67qn-0273

Study Description: The data herein combined GC-MS and GC-DMS analysis of exhaled breath vapor compounds. The intent of this study was to develop a portable GC-DMS system to diagnose SARS-CoV-2 infections from a breath sample. The data were collected from hundreds of subjects in an IRB-sanctioned study. Breath vapor samples were collected from COVID-19(+) patients, including asymptomatic and symptomatic, and from healthy COVID-19(-) controls. Relevant human demographic information was also collected such as age, gender, height, weight, symptoms at time of sampling, etc.

Updated Date: 01/18/2024

Principal Investigator: Davis, Cristina Elizabeth

Has Data Files: Yes

Study Domain: Novel Biosensing or VOC; Virological Testing

Data Collection Method: Breath Analysis or Airborne Detection Device

Keywords: COVID-Positive Patients

Study Design: Device Validation

Multi-Center Study: No

Data Types: Clinical; Electronic Medical Records; Metabolomic; Questionnaire or Survey

Study Start Date: 12/21/2020

Study End Date: 02/28/2023

Species: Human

Estimated Cohort Size: 700

Study Population Focus: Adults; Older Adults or Elderly

Publication URL: https://pubmed.ncbi.nlm.nih.gov/33616417/; https://pubmed.ncbi.nlm.nih.gov/33616417/; https://pubmed.ncbi.nlm.nih.gov/33858010/; https://pubmed.ncbi.nlm.nih.gov/33858010/; https://pubmed.ncbi.nlm.nih.gov/34343985/; https://pubmed.ncbi.nlm.nih.gov/34663766/; https://pubmed.ncbi.nlm.nih.gov/34663766/; https://pubmed.ncbi.nlm.nih.gov/34852327/; https://pubmed.ncbi.nlm.nih.gov/34852327/; https://pubmed.ncbi.nlm.nih.gov/35508102/; https://pubmed.ncbi.nlm.nih.gov/35508102/; https://pubmed.ncbi.nlm.nih.gov/35968834/; https://pubmed.ncbi.nlm.nih.gov/35968834/; https://pubmed.ncbi.nlm.nih.gov/36363914/; https://pubmed.ncbi.nlm.nih.gov/36363914/; https://pubmed.ncbi.nlm.nih.gov/36482179/; https://pubmed.ncbi.nlm.nih.gov/36482179/; https://pubmed.ncbi.nlm.nih.gov/37207635/; https://pubmed.ncbi.nlm.nih.gov/37207635/; https://pubmed.ncbi.nlm.nih.gov/37216348/

Acknowledgement Statement: This study was supported through funding, 4U18TR003795-02, for the National Center for Advancing Translational Sciences (NCATS) as part of the RADx-rad program. Approved users should acknowledge the provision of data access by dbGaP for accession phs002600.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.

Funding Opportunity Announcement (FOA) Number: RFA-OD-20-017

NIH Grant or Contract Number(s): 4U18TR003795-02

Consent/Data Use Limitations: General Research Use

Variable Information
Total Variables: 191
Study Variables Information Table
Variable Name
Label
nih_record_idUser ID
nih_raceWhat is your race?
nih_ethnicityAre you of Hispanic or Latino origin? May include Spanish origin.
nih_ageWhat is your age?
nih_sexWhat is your biological sex assigned at birth?
nih_education_yrsHow many years of education have you completed?
nih_zipWhat is your zip code?
nih_employmentPlease specify your employment status.
nih_insuranceWhat kind of health insurance do you have?
nih_deafAre you deaf or do you have serious difficulty hearing?
nih_blindAre you blind or do you have serious difficulty seeing, even when wearing glasses?
nih_memoryBecause of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions?
nih_walk_climbDo you have serious difficulty walking or climbing stairs?
nih_dress_batheDo you have difficulty dressing or bathing?
nih_errandBecause of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping?
nih_vaping_ynVaping use (Yes or No)
nih_nicotine_ynNicotine use (Yes or No)
nih_alcohol_ynAlcohol use (Yes or No)
nih_asthmaAsthma
nih_cancerCancer
nih_cardiovascular_diseaseCardiovascular disease
nih_chronic_kidney_diseaseChronic kidney disease
nih_chronic_lung_diseaseChronic lung disease
nih_diabetesDiabetes
nih_hypertensionHypertension
nih_immunosuppressive_conditionImmunosuppressive condition
nih_serious_mental_illnessSerious mental illness
nih_sickle_cell_diseaseSickle cell disease
nih_pregnancyPregnancy status
nih_coughCough
nih_fever_chillsFever or Chills
nih_diff_breathShortness of breath or difficulty breathing
nih_headacheHeadache
nih_muscle_acheMuscle ache
nih_olfactoryNew loss of taste or smell
nih_fatigueExcessive fatigue
nih_nausea_vomiting_diarrheaNausea, vomiting, or diarrhea
nih_abdom_painAbdominal pain
nih_skin_rashSkin rash
nih_conjunctivitisConjunctivitis
nih_health_statusWould you say that (your) health in general is excellent, very good, good, fair, or poor?
nih_heightWhat is your height in inches?
nih_weightWhat is your weight in pounds?
abdominal_painAbdominal pain
ageWhat is your age? (Age in years. For babies less than 1 year old, write 0 as the age)
alcohol_useAlcohol Use
asthmaAsthma
blindAre you blind or do you have serious difficulty seeing, even when wearing glasses?
cancerCancer
cardiovascular_diseaseCardiovascular disease
chillsChills
chronic_kidney_diseaseChronic kidney disease
chronic_lung_diseaseChronic lung disease
conjunctivitisConjunctivitis
coughCough
deafAre you deaf or do you have serious difficulty hearing?
diabetesDiabetes
diarrheaDiarrhea
dress_bathe_disDo you have difficulty dressing or bathing?
educationHow many years of education have you completed? (Years of education from 0 - 20+)
employmentAre you employed?
errand_disBecause of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping?
ethnicityAre you of Hispanic or Latino origin?
excessive_fatigueExcessive fatigue
feverFever
headacheHeadache
health_statusWould you say that (your) health in general is excellent, very good, good, fair or poor?
height_feetHeight Feet
height_inchesHeight Inches
hypertensionHypertension
immunosuppressive_conditioImmunosuppressive condition
insuranceWhat kind of health insurance do you have?
memory_disBecause of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions?
muscle_acheMuscle ache
nausea_vomitingNausea/vomiting
new_loss_of_taste_or_smellNew loss of taste or smell
nicotineNicotine Use
pregnancy_statusPregnancy status
raceWhat is your race? Mark one or more boxes.
serious_mental_illnessSerious mental illness
sexWhat is your biological sex assigned at birth?
shortness_of_breath_or_difShortness of breath or difficulty breathing
sickle_cell_diseaseSickle cell disease
skin_rashSkin rash
vapingVaping Use
walking_climbing_disDo you have serious difficulty walking or climbing stairs?
weight_lbsWhat is your weight? (Weight in pounds)
zipZip or Postal Code: (De-Identified zip code)
analyte_type-
clinical_sensitivity-
clinical_sensitivity_ci_max-
clinical_sensitivity_ci_min-
clinical_sensitivity_ci_percent-
clinical_specificity-
clinical_specificity_ci_max-
clinical_specificity_ci_min-
clinical_specificity_ci_percent-
cohort_id-
cohort_size-
covid_test_result-
covid_vaccine-
covid_vaccine_doses-
cryo_cooling_temperature_max-
cryo_cooling_temperature_max_unit-
cryo_cooling_temperature_min-
cryo_cooling_temperature_min_unit-
cryo_cooling_temperature_ramp-
cryo_cooling_temperature_ramp_unit-
cryo_cooling_time_max-
cryo_cooling_time_max_unit-
desorption_temperature_max-
desorption_temperature_max_unit-
desorption_temperature_min-
desorption_temperature_min_unit-
desorption_temperature_ramp-
desorption_temperature_ramp_unit-
desorption_time-
desorption_time_min-
desorption_time_min_unit-
desorption_time_unit-
false_negatives-
false_positives-
gc_carrier_gas-
gc_column-
gc_column_film_thickness-
gc_column_film_thickness_unit-
gc_column_flow-
gc_column_flow_unit-
gc_column_inner_diameter-
gc_column_inner_diameter_unit-
gc_column_length-
gc_column_length_unit-
gc_column_source-
gc_column_source_url-
gc_injection_method-
gc_injection_method_source-
gc_injection_method_source_url-
gcms_total_runtime-
gcms_total_runtime_unit-
gc_oven_first_temperature_ramp-
gc_oven_first_temperature_ramp_unit-
gc_oven_second_temperature_ramp-
gc_oven_second_temperature_ramp_unit-
gc_oven_start_temperature-
gc_oven_start_temperature_hold_time-
gc_oven_start_temperature_hold_time_unit-
gc_oven_start_temperature_unit-
gc_oven_temperature_end_first_ramp-
gc_oven_temperature_end_first_ramp_unit-
gc_oven_temperature_end_second_ramp-
gc_oven_temperature_end_second_ramp_unit-
gc_oven_temperature_end_third_ramp-
gc_oven_temperature_end_third_ramp_unit-
gc_oven_third_temperature_ramp-
gc_oven_third_temperature_ramp_unit-
gender_identity-
measurement_type-
ms_ionization_temperature-
ms_ionization_temperature_unit-
ms_ionization_type-
ms_ionization_voltage-
ms_ionization_voltage_unit-
ms_scan_range_max-
ms_scan_range_min-
ms_scan_range_unit-
ms_scan_type-
negative_predictive_value-
negative_predictive_value_ci_max-
negative_predictive_value_ci_min-
negative_predictive_value_ci_percent-
peak_id-
peak_mass-
peak_mass_unit-
peak_retention_time-
peak_retention_time_unit-
positive_predictive_value-
positive_predictive_value_ci_max-
positive_predictive_value_ci_min-
positive_predictive_value_ci_percent-
protocol_id-
signal_detection-
specimen_type-
study_id-
study_population-
technology_description-
technology_platform-
technology_reference-
true_negatives-
true_positives-
voc_compound_name-
voc_relative_abundance-
Data Files
Total Files: 15
Data Files: 5
Metadata Files: 5
Dictionary Files: 5
Study Datasets Table
File Name
File Type
File Format(s)
# of Records
# of Variables
Metadata
Dictionary
rad_017_795-01_technology_DATA_origcopy.csvTabular Data - Non-harmonizedcsv1
rad_017_795-01_performance_DATA_origcopy.csvTabular Data - Non-harmonizedcsv3
rad_017_795-01_subject_DATA_origcopy.csvTabular Data - Non-harmonizedcsv213
rad_017_795-01_subject_DATA_transformcopy.csvTabular Data - Harmonizedcsv213
rad_017_795-01_voc_DATA_origcopy.csvTabular Data - Non-harmonizedcsv15120