dbGaP Study Accession: phs002600
NIH Institute/Center: NCATS
RADx Data Program: RADx-rad
Release Date: 08/02/2022
DOI: 10.60773/67qn-0273
Study Description: The data herein combined GC-MS and GC-DMS analysis of exhaled breath vapor compounds. The intent of this study was to develop a portable GC-DMS system to diagnose SARS-CoV-2 infections from a breath sample. The data were collected from hundreds of subjects in an IRB-sanctioned study. Breath vapor samples were collected from COVID-19(+) patients, including asymptomatic and symptomatic, and from healthy COVID-19(-) controls. Relevant human demographic information was also collected such as age, gender, height, weight, symptoms at time of sampling, etc.
Updated Date: 01/18/2024
Principal Investigator: Davis, Cristina Elizabeth
Has Data Files: Yes
Study Domain: Novel Biosensing or VOC; Virological Testing
Data Collection Method: Breath Analysis or Airborne Detection Device
Keywords: COVID-Positive Patients
Study Design: Device Validation
Multi-Center Study: No
Data Types: Clinical; Electronic Medical Records; Metabolomic; Questionnaire or Survey
Study Start Date: 12/21/2020
Study End Date: 02/28/2023
Species: Human
Estimated Cohort Size: 700
Study Population Focus: Adults; Older Adults or Elderly
Publication URL: https://pubmed.ncbi.nlm.nih.gov/33616417/; https://pubmed.ncbi.nlm.nih.gov/33616417/; https://pubmed.ncbi.nlm.nih.gov/33858010/; https://pubmed.ncbi.nlm.nih.gov/33858010/; https://pubmed.ncbi.nlm.nih.gov/34343985/; https://pubmed.ncbi.nlm.nih.gov/34663766/; https://pubmed.ncbi.nlm.nih.gov/34663766/; https://pubmed.ncbi.nlm.nih.gov/34852327/; https://pubmed.ncbi.nlm.nih.gov/34852327/; https://pubmed.ncbi.nlm.nih.gov/35508102/; https://pubmed.ncbi.nlm.nih.gov/35508102/; https://pubmed.ncbi.nlm.nih.gov/35968834/; https://pubmed.ncbi.nlm.nih.gov/35968834/; https://pubmed.ncbi.nlm.nih.gov/36363914/; https://pubmed.ncbi.nlm.nih.gov/36363914/; https://pubmed.ncbi.nlm.nih.gov/36482179/; https://pubmed.ncbi.nlm.nih.gov/36482179/; https://pubmed.ncbi.nlm.nih.gov/37207635/; https://pubmed.ncbi.nlm.nih.gov/37207635/; https://pubmed.ncbi.nlm.nih.gov/37216348/
Acknowledgement Statement: This study was supported through funding, 4U18TR003795-02, for the National Center for Advancing Translational Sciences (NCATS) as part of the RADx-rad program. Approved users should acknowledge the provision of data access by dbGaP for accession phs002600.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.
Funding Opportunity Announcement (FOA) Number: RFA-OD-20-017
NIH Grant or Contract Number(s): 4U18TR003795-02
Consent/Data Use Limitations: General Research Use
Variable Name | Label |
|---|---|
| nih_record_id | User ID |
| nih_race | What is your race? |
| nih_ethnicity | Are you of Hispanic or Latino origin? May include Spanish origin. |
| nih_age | What is your age? |
| nih_sex | What is your biological sex assigned at birth? |
| nih_education_yrs | How many years of education have you completed? |
| nih_zip | What is your zip code? |
| nih_employment | Please specify your employment status. |
| nih_insurance | What kind of health insurance do you have? |
| nih_deaf | Are you deaf or do you have serious difficulty hearing? |
| nih_blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
| nih_memory | Because of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions? |
| nih_walk_climb | Do you have serious difficulty walking or climbing stairs? |
| nih_dress_bathe | Do you have difficulty dressing or bathing? |
| nih_errand | Because of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping? |
| nih_vaping_yn | Vaping use (Yes or No) |
| nih_nicotine_yn | Nicotine use (Yes or No) |
| nih_alcohol_yn | Alcohol use (Yes or No) |
| nih_asthma | Asthma |
| nih_cancer | Cancer |
| nih_cardiovascular_disease | Cardiovascular disease |
| nih_chronic_kidney_disease | Chronic kidney disease |
| nih_chronic_lung_disease | Chronic lung disease |
| nih_diabetes | Diabetes |
| nih_hypertension | Hypertension |
| nih_immunosuppressive_condition | Immunosuppressive condition |
| nih_serious_mental_illness | Serious mental illness |
| nih_sickle_cell_disease | Sickle cell disease |
| nih_pregnancy | Pregnancy status |
| nih_cough | Cough |
| nih_fever_chills | Fever or Chills |
| nih_diff_breath | Shortness of breath or difficulty breathing |
| nih_headache | Headache |
| nih_muscle_ache | Muscle ache |
| nih_olfactory | New loss of taste or smell |
| nih_fatigue | Excessive fatigue |
| nih_nausea_vomiting_diarrhea | Nausea, vomiting, or diarrhea |
| nih_abdom_pain | Abdominal pain |
| nih_skin_rash | Skin rash |
| nih_conjunctivitis | Conjunctivitis |
| nih_health_status | Would you say that (your) health in general is excellent, very good, good, fair, or poor? |
| nih_height | What is your height in inches? |
| nih_weight | What is your weight in pounds? |
| abdominal_pain | Abdominal pain |
| age | What is your age? (Age in years. For babies less than 1 year old, write 0 as the age) |
| alcohol_use | Alcohol Use |
| asthma | Asthma |
| blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
| cancer | Cancer |
| cardiovascular_disease | Cardiovascular disease |
| chills | Chills |
| chronic_kidney_disease | Chronic kidney disease |
| chronic_lung_disease | Chronic lung disease |
| conjunctivitis | Conjunctivitis |
| cough | Cough |
| deaf | Are you deaf or do you have serious difficulty hearing? |
| diabetes | Diabetes |
| diarrhea | Diarrhea |
| dress_bathe_dis | Do you have difficulty dressing or bathing? |
| education | How many years of education have you completed? (Years of education from 0 - 20+) |
| employment | Are you employed? |
| errand_dis | Because of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping? |
| ethnicity | Are you of Hispanic or Latino origin? |
| excessive_fatigue | Excessive fatigue |
| fever | Fever |
| headache | Headache |
| health_status | Would you say that (your) health in general is excellent, very good, good, fair or poor? |
| height_feet | Height Feet |
| height_inches | Height Inches |
| hypertension | Hypertension |
| immunosuppressive_conditio | Immunosuppressive condition |
| insurance | What kind of health insurance do you have? |
| memory_dis | Because of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions? |
| muscle_ache | Muscle ache |
| nausea_vomiting | Nausea/vomiting |
| new_loss_of_taste_or_smell | New loss of taste or smell |
| nicotine | Nicotine Use |
| pregnancy_status | Pregnancy status |
| race | What is your race? Mark one or more boxes. |
| serious_mental_illness | Serious mental illness |
| sex | What is your biological sex assigned at birth? |
| shortness_of_breath_or_dif | Shortness of breath or difficulty breathing |
| sickle_cell_disease | Sickle cell disease |
| skin_rash | Skin rash |
| vaping | Vaping Use |
| walking_climbing_dis | Do you have serious difficulty walking or climbing stairs? |
| weight_lbs | What is your weight? (Weight in pounds) |
| zip | Zip or Postal Code: (De-Identified zip code) |
| analyte_type | - |
| clinical_sensitivity | - |
| clinical_sensitivity_ci_max | - |
| clinical_sensitivity_ci_min | - |
| clinical_sensitivity_ci_percent | - |
| clinical_specificity | - |
| clinical_specificity_ci_max | - |
| clinical_specificity_ci_min | - |
| clinical_specificity_ci_percent | - |
| cohort_id | - |
| cohort_size | - |
| covid_test_result | - |
| covid_vaccine | - |
| covid_vaccine_doses | - |
| cryo_cooling_temperature_max | - |
| cryo_cooling_temperature_max_unit | - |
| cryo_cooling_temperature_min | - |
| cryo_cooling_temperature_min_unit | - |
| cryo_cooling_temperature_ramp | - |
| cryo_cooling_temperature_ramp_unit | - |
| cryo_cooling_time_max | - |
| cryo_cooling_time_max_unit | - |
| desorption_temperature_max | - |
| desorption_temperature_max_unit | - |
| desorption_temperature_min | - |
| desorption_temperature_min_unit | - |
| desorption_temperature_ramp | - |
| desorption_temperature_ramp_unit | - |
| desorption_time | - |
| desorption_time_min | - |
| desorption_time_min_unit | - |
| desorption_time_unit | - |
| false_negatives | - |
| false_positives | - |
| gc_carrier_gas | - |
| gc_column | - |
| gc_column_film_thickness | - |
| gc_column_film_thickness_unit | - |
| gc_column_flow | - |
| gc_column_flow_unit | - |
| gc_column_inner_diameter | - |
| gc_column_inner_diameter_unit | - |
| gc_column_length | - |
| gc_column_length_unit | - |
| gc_column_source | - |
| gc_column_source_url | - |
| gc_injection_method | - |
| gc_injection_method_source | - |
| gc_injection_method_source_url | - |
| gcms_total_runtime | - |
| gcms_total_runtime_unit | - |
| gc_oven_first_temperature_ramp | - |
| gc_oven_first_temperature_ramp_unit | - |
| gc_oven_second_temperature_ramp | - |
| gc_oven_second_temperature_ramp_unit | - |
| gc_oven_start_temperature | - |
| gc_oven_start_temperature_hold_time | - |
| gc_oven_start_temperature_hold_time_unit | - |
| gc_oven_start_temperature_unit | - |
| gc_oven_temperature_end_first_ramp | - |
| gc_oven_temperature_end_first_ramp_unit | - |
| gc_oven_temperature_end_second_ramp | - |
| gc_oven_temperature_end_second_ramp_unit | - |
| gc_oven_temperature_end_third_ramp | - |
| gc_oven_temperature_end_third_ramp_unit | - |
| gc_oven_third_temperature_ramp | - |
| gc_oven_third_temperature_ramp_unit | - |
| gender_identity | - |
| measurement_type | - |
| ms_ionization_temperature | - |
| ms_ionization_temperature_unit | - |
| ms_ionization_type | - |
| ms_ionization_voltage | - |
| ms_ionization_voltage_unit | - |
| ms_scan_range_max | - |
| ms_scan_range_min | - |
| ms_scan_range_unit | - |
| ms_scan_type | - |
| negative_predictive_value | - |
| negative_predictive_value_ci_max | - |
| negative_predictive_value_ci_min | - |
| negative_predictive_value_ci_percent | - |
| peak_id | - |
| peak_mass | - |
| peak_mass_unit | - |
| peak_retention_time | - |
| peak_retention_time_unit | - |
| positive_predictive_value | - |
| positive_predictive_value_ci_max | - |
| positive_predictive_value_ci_min | - |
| positive_predictive_value_ci_percent | - |
| protocol_id | - |
| signal_detection | - |
| specimen_type | - |
| study_id | - |
| study_population | - |
| technology_description | - |
| technology_platform | - |
| technology_reference | - |
| true_negatives | - |
| true_positives | - |
| voc_compound_name | - |
| voc_relative_abundance | - |