dbGaP Study Accession: phs002964
NIH Institute/Center: NIDCD
RADx Data Program: RADx-rad
DOI: 10.60773/xb7r-qw92
Release Date: 08/30/2024
Study Description: Self-report of sudden loss of smell or taste substantially increases the odds of being infected with SARS-CoV-2. However, self-report of smell function is an unreliable predictor of smell loss. The study created a self-administered easy to use "at home" 5-minute objective smell test to uncover alterations in smell function unbeknownst to many individuals and confer increased risk of infection by SARS- CoV-2. The new smell test consists of a physical smell card containing peel and sniff odor labels and a web- based application. Each participant accessed the web-based app on their own smartphone, tablet, or computer. The study developed a native app to conduct longitudinal COVID Smell Test (Aim 1), collect data on asymptomatic health care workers, symptomatic patients, and undergraduates (Aim 2) and develop algorithms for the longitudinal smell test for personalized thresholds, differentiate smell loss from COVID relative to influenza (Aim 3). The Longitudinal COVID Smell Test was accessible, affordable, and readily scalable. Effective screening with the COVID smell test better informed students and employees if they should not report to school or work and seek an evaluation by a healthcare professional.
Updated Date: 01/18/2024
Principal Investigator: Albers, Mark
Has Data Files: Yes
Study Domain: At-Home or Over-the-Counter (OTC) Self-Testing; Diagnostic Testing; Digital Health Applications; Influenza
Data Collection Method: Chemosensory Testing Device
Keywords: Anosmia; Ansomic Patients; Healthcare Workers; Odor Discrimination; Odor Identification; Odor Intensity; Olfaction; Olfactory Function; Olfactory Testing; Smell Function; Smell Test; Symptomatic Population
Study Design: Longitudinal Cohort
Multi-Center Study: Yes
Study Sites: University of Maryland
Data Types: Clinical; Electronic Medical Records; Questionnaire or Survey
Study Start Date: 12/21/2020
Study End Date: 05/31/2023
Species: Human
Estimated Cohort Size: 6000
Study Population Focus: Adults; Essential Workers; Older Adults or Elderly
Study Website URL: https://rally.massgeneralbrigham.org/study/at_home_covidsmell_test_
ClinicalTrials.gov URL: https://clinicaltrials.gov/study/NCT05040659
Acknowledgement Statement: This study was supported through funding, 4U01DC019579-03, for the National Institute on Deafness and Other Communication Disorders (NIDCD) as part of the RADx-rad program. This work was supported by Principal Investigator Dr. Mark Albers. A special acknowledgment to our Collaborating site, University of Maryland, our study team, research staff, and the study participants that made this project possible. Approved users should acknowledge the provision of data access by dbGaP for accession phs002964.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.
Funding Opportunity Announcement (FOA) Number: RFA-OD-20-022
NIH Grant or Contract Number(s): 4U01DC019579-03
Consent/Data Use Limitations: General Research Use
Variable Name | Label |
---|---|
nih_record_id | User ID |
nih_race | What is your race? |
nih_ethnicity | Are you of Hispanic or Latino origin? May include Spanish origin. |
nih_age | What is your age? |
nih_sex | What is your biological sex assigned at birth? |
nih_education_yrs | How many years of education have you completed? |
nih_zip | What is your zip code? |
nih_employment | Please specify your employment status. |
nih_insurance | What kind of health insurance do you have? |
nih_deaf | Are you deaf or do you have serious difficulty hearing? |
nih_blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
nih_memory | Because of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions? |
nih_walk_climb | Do you have serious difficulty walking or climbing stairs? |
nih_dress_bathe | Do you have difficulty dressing or bathing? |
nih_errand | Because of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping? |
nih_vaping_yn | Vaping use (Yes or No) |
nih_nicotine_yn | Nicotine use (Yes or No) |
nih_alcohol_yn | Alcohol use (Yes or No) |
nih_asthma | Asthma |
nih_cancer | Cancer |
nih_cardiovascular_disease | Cardiovascular disease |
nih_chronic_kidney_disease | Chronic kidney disease |
nih_chronic_lung_disease | Chronic lung disease |
nih_diabetes | Diabetes |
nih_hypertension | Hypertension |
nih_immunosuppressive_condition | Immunosuppressive condition |
nih_serious_mental_illness | Serious mental illness |
nih_sickle_cell_disease | Sickle cell disease |
nih_pregnancy | Pregnancy status |
nih_cough | Cough |
nih_fever_chills | Fever or Chills |
nih_diff_breath | Shortness of breath or difficulty breathing |
nih_headache | Headache |
nih_muscle_ache | Muscle ache |
nih_olfactory | New loss of taste or smell |
nih_fatigue | Excessive fatigue |
nih_nausea_vomiting_diarrhea | Nausea, vomiting, or diarrhea |
nih_abdom_pain | Abdominal pain |
nih_skin_rash | Skin rash |
nih_conjunctivitis | Conjunctivitis |
nih_health_status | Would you say that (your) health in general is excellent, very good, good, fair, or poor? |
nih_height | What is your height in inches? |
nih_weight | What is your weight in pounds? |
abdominal_pain | Abdominal pain |
age | What is your age? (Age in years. For babies less than 1 year old, write 0 as the age) |
alcohol_use | Alcohol Use |
asthma | Asthma |
blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
cancer | Cancer |
cardiovascular_disease | Cardiovascular disease |
chills | Chills |
chronic_kidney_disease | Chronic kidney disease |
chronic_lung_disease | Chronic lung disease |
conjunctivitis | Conjunctivitis |
cough | Cough |
deaf | Are you deaf or do you have serious difficulty hearing? |
diabetes | Diabetes |
diarrhea | Diarrhea |
dress_bathe_dis | Do you have difficulty dressing or bathing? |
education | How many years of education have you completed? (Years of education from 0 - 20+) |
employment | Are you employed? |
errand_dis | Because of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping? |
ethnicity | Are you of Hispanic or Latino origin? |
excessive_fatigue | Excessive fatigue |
fever | Fever |
headache | Headache |
health_status | Would you say that (your) health in general is excellent, very good, good, fair or poor? |
height_feet | Height Feet |
height_inches | Height Inches |
hypertension | Hypertension |
immunosuppressive_conditio | Immunosuppressive condition |
insurance | What kind of health insurance do you have? |
memory_dis | Because of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions? |
muscle_ache | Muscle ache |
nausea_vomiting | Nausea/vomiting |
new_loss_of_taste_or_smell | New loss of taste or smell |
nicotine | Nicotine Use |
pregnancy_status | Pregnancy status |
race | What is your race? Mark one or more boxes. |
serious_mental_illness | Serious mental illness |
sex | What is your biological sex assigned at birth? |
shortness_of_breath_or_dif | Shortness of breath or difficulty breathing |
sickle_cell_disease | Sickle cell disease |
skin_rash | Skin rash |
vaping | Vaping Use |
walking_climbing_dis | Do you have serious difficulty walking or climbing stairs? |
weight_lbs | What is your weight? (Weight in pounds) |
zip | Zip or Postal Code: (De-Identified zip code) |
assay_readout | - |
assay_readout_description | - |
cohort_id | - |
covid_diagnosis | - |
covid_test_result | - |
covid_test_specimen_collector | - |
covid_test_specimen_type | - |
covid_test_specimen_type_other | - |
covid_test_type | - |
covid_vaccine_doses | - |
date_enrolled | - |
days_since_most_recent_vaccine | - |
days_since_patient_covid_positive | - |
measurement_type | - |
odorant | - |
odorant_test_max | - |
odorant_test_min | - |
protocol_id | - |
signal_detection | - |
study_id | - |
symptom_onset_days | - |
technology_description | - |
technology_platform | - |
timepoint | - |