dbGaP Study Accession: phs002945
NIH Institute/Center: NICHD
RADx Data Program: RADx-rad
DOI: 10.60773/277p-e595
Release Date: 11/07/2022
Study Description: The primary objective of this study was to design and validate a predictive decision support system for the identification, treatment and management of SARS-CoV-2 associated with multisystem inflammatory syndrome in children (MIS-C). To develop this system, the study adapted and retrained machine learning algorithms which have previously trained in patients with Kawasaki Disease, a pediatric inflammatory vasculopathy with clinical overlap with MIS-C but different etiology. This study, performed in collaboration with the International Kawasaki Disease Registry (IKDR) consortium. This dataset contains the development and international validation data for all algorithms developed as part of this study.
Updated Date: 12/09/2022
Principal Investigator: Manlhiot, Cedric
Has Data Files: Yes
Study Domain: Artificial Intelligence or Machine Learning; Multisystem Inflammatory Syndrome (MIS); Multisystem Inflammatory Syndrome in Children (MIS-C)
Data Collection Method: Disease Registry
Keywords: Kawasaki; Pediatrics
Study Design: Cross-Sectional
Multi-Center Study: Yes
Study Sites: See attached list
Data Types: Clinical; Electronic Medical Records; Environmental; Family History; Individual Phenotype; Questionnaire or Survey
Study Start Date: 01/01/2021
Study End Date: 04/30/2022
Species: Human
Estimated Cohort Size: 900
Study Population Focus: Children
Publication URL: https://pubmed.ncbi.nlm.nih.gov/35624313/; https://pubmed.ncbi.nlm.nih.gov/36455760/; https://pubmed.ncbi.nlm.nih.gov/36947454/; https://pubmed.ncbi.nlm.nih.gov/37290536/
Acknowledgement Statement: This study was supported through funding, 4R61HD105591-02, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) as part of the RADx-rad program. Data for this study was acquired through the International Kawasaki Disease Registry (IKDR). Approved users should acknowledge the provision of data access by dbGaP for accession phs002945.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.
Funding Opportunity Announcement (FOA) Number: RFA-OD-20-023
NIH Grant or Contract Number(s): 4R61HD105591-02
Consent/Data Use Limitations: General Research Use; IRB required
Variable Name | Label |
---|---|
nih_record_id | User ID |
nih_race | What is your race? |
nih_ethnicity | Are you of Hispanic or Latino origin? May include Spanish origin. |
nih_age | What is your age? |
nih_sex | What is your biological sex assigned at birth? |
nih_education_yrs | How many years of education have you completed? |
nih_zip | What is your zip code? |
nih_employment | Please specify your employment status. |
nih_insurance | What kind of health insurance do you have? |
nih_deaf | Are you deaf or do you have serious difficulty hearing? |
nih_blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
nih_vaping_yn | Vaping use (Yes or No) |
nih_nicotine_yn | Nicotine use (Yes or No) |
nih_alcohol_yn | Alcohol use (Yes or No) |
nih_asthma | Asthma |
nih_cancer | Cancer |
nih_cardiovascular_disease | Cardiovascular disease |
nih_chronic_kidney_disease | Chronic kidney disease |
nih_chronic_lung_disease | Chronic lung disease |
nih_diabetes | Diabetes |
nih_hypertension | Hypertension |
nih_immunosuppressive_condition | Immunosuppressive condition |
nih_serious_mental_illness | Serious mental illness |
nih_sickle_cell_disease | Sickle cell disease |
nih_pregnancy | Pregnancy status |
nih_cough | Cough |
nih_fever_chills | Fever or Chills |
nih_diff_breath | Shortness of breath or difficulty breathing |
nih_headache | Headache |
nih_muscle_ache | Muscle ache |
nih_olfactory | New loss of taste or smell |
nih_fatigue | Excessive fatigue |
nih_nausea_vomiting_diarrhea | Nausea, vomiting, or diarrhea |
nih_abdom_pain | Abdominal pain |
nih_skin_rash | Skin rash |
nih_conjunctivitis | Conjunctivitis |
nih_height | What is your height in inches? |
nih_weight | What is your weight in pounds? |
abdominal_pain | Abdominal pain |
age | What is your age? (Age in years. For babies less than 1 year old, write 0 as the age) |
alcohol_use | Alcohol Use |
asthma | Asthma |
blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
cancer | Cancer |
cardiovascular_disease | Cardiovascular disease |
chills | Chills |
chronic_kidney_disease | Chronic kidney disease |
chronic_lung_disease | Chronic lung disease |
conjunctivitis | Conjunctivitis |
cough | Cough |
deaf | Are you deaf or do you have serious difficulty hearing? |
diabetes | Diabetes |
diarrhea | Diarrhea |
education | How many years of education have you completed? (Years of education from 0 - 20+) |
employment | Are you employed? |
ethnicity | Are you of Hispanic or Latino origin? |
excessive_fatigue | Excessive fatigue |
fever | Fever |
headache | Headache |
height_feet | Height Feet |
height_inches | Height Inches |
hypertension | Hypertension |
immunosuppressive_conditio | Immunosuppressive condition |
insurance | What kind of health insurance do you have? |
muscle_ache | Muscle ache |
nausea_vomiting | Nausea/vomiting |
new_loss_of_taste_or_smell | New loss of taste or smell |
nicotine | Nicotine Use |
pregnancy_status | Pregnancy status |
race | What is your race? Mark one or more boxes. |
serious_mental_illness | Serious mental illness |
sex | What is your biological sex assigned at birth? |
shortness_of_breath_or_dif | Shortness of breath or difficulty breathing |
sickle_cell_disease | Sickle cell disease |
skin_rash | Skin rash |
vaping | Vaping Use |
weight_lbs | What is your weight? (Weight in pounds) |
zip | Zip or Postal Code: (De-Identified zip code) |
anorexia | - |
cpl_kd | - |
criteria | - |
dress_bathe_dis_pediatric | - |
DS_HOSPINF | - |
dx_covid | - |
dx_kd | - |
dx_misc | - |
education_parent_A | - |
education_parent_B | - |
employment_parent_A | - |
employment_parent_B | - |
errand_dis_1 | - |
errand_dis_2 | - |
inc_kd | - |
irritability | - |
memory_dis_1 | - |
memory_dis_2 | - |
r_allergies | - |
rds_highesttemp | - |
r_familyimm | - |
r_familykd | - |
r_gestwk | - |
r_inf_contact6wk | - |
r_inf_stat | - |
r_prevkd | - |
r_week | - |
study_id | - |
walking_climbing_dis_1 | - |
walking_climbing_dis_2 | - |
year | - |