dbGaP Study Accession: phs003360
NIH Institute/Center: NIBIB
RADx Data Program: RADx Tech
DOI: 10.60773/jrhz-2h83
Release Date: 04/17/2024
Study Description: The COVID Detect/COVID-19 viral dynamics study was planned and performed to assess SARS-CoV-2 viral dynamics in early infection, accuracy/persistence of SARS-CoV-2 antigen/PCR testing, clinical aspects of mild COVID-19, and potential SARS-CoV-2 transmission dynamics or risk factors. This study included a cohort of adult students and employees of University of Illinois Urbana-Champaign (UIUC) and Northwestern University who tested positive for SARS-CoV-2 as part of campus surveillance programs (isolation participants) or close contacts (particularly roommates) of individuals testing positive for SARS-CoV-2 (quarantine participants). Isolation participants were enrolled within 24 hours of positive testing and quarantine participants were enrolled within 5 days of last known exposure. All participants were required to have negative campus surveillance testing within 7 days of enrollment. Isolation participants completed daily surveys and collected observed nasal swabs and saliva (UIUC only) for 14 days. Quarantine participants completed daily surveys and collected samples for 7 days if SARS-CoV-2 RT-PCR remained negative; if converted positive by SARS-CoV-2 PCR, they collected daily samples for full 14 days. Each day of sample collection were analyzed as follows: nasal swab for SARS-CoV-2 POC Quidel antigen, nasal swab into VTM for SARS-CoV-2 Roche RT-PCR, saliva for SARS-CoV-2 PCR (UIUC only), and nasal swab into VTM for storage and subsequent whole genome virus sequencing and viral culture assay.
Updated Date: 04/17/2024
Principal Investigator: Mcmanus, David
Has Data Files: Yes
Study Domain: Rapid Diagnostic Test (RDT)
Data Collection Method: Antigen Testing Device; Molecular Nucleic Acid or PCR Testing Device; Smartphone; Survey
Keywords: COVID Risk Factors; COVID Transmission Dynamics; COVID-positive Patients; Congregate Settings; Early Infection; People Living in Congregate Settings; People with Known COVID Exposure; Viral Dynamics
Study Design: Longitudinal Cohort
Multi-Center Study: Yes
Study Sites: University of Illinois Urbana-Champaign and Northwestern University
Data Types: Biologic Specimens; Clinical; Immunological; Questionnaire or Survey
Study Start Date: 12/02/2020
Study End Date: 06/02/2021
Species: Human
Estimated Cohort Size: 300
Study Population Focus: Adults; Older Adults or Elderly
Acknowledgement Statement: This study was supported through funding, 3U54HL143541-05S1, for the National Institute of Biomedical Imaging and Bioengineering (NIBIB) as part of the RADx Tech program. This work was also supported by the National Institute of Biomedical Imaging and Bioengineering through the Center for Innovation in Point of Care Technologies for HIV/AIDS at Northwestern (C-THAN) [3U54EB027049-02S1]. Approved users should acknowledge the provision of data access by dbGaP for accession phs003360.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.
Funding Opportunity Announcement (FOA) Number: PA-20-272
NIH Grant or Contract Number(s): 3U54HL143541-05S1
Consent/Data Use Limitations: General Research Use; Disease-Specific for COVID-19
Variable Name | Label |
---|---|
nih_record_id | User ID |
nih_race | What is your race? |
nih_ethnicity | Are you of Hispanic or Latino origin? May include Spanish origin. |
nih_age | What is your age? |
nih_sex | What is your biological sex assigned at birth? |
nih_education | What is the highest level of education you have achieved outside or in the United States? |
nih_zip | What is your zip code? |
nih_employment | Please specify your employment status. |
nih_insurance | What kind of health insurance do you have? |
nih_disability | Do you have a disability, including serious physical or mental conditions, that interfere with your ability to carry out daily activities? |
nih_deaf | Are you deaf or do you have serious difficulty hearing? |
nih_blind | Are you blind or do you have serious difficulty seeing, even when wearing glasses? |
nih_memory | Because of a physical, mental, or emotional condition, do you have serious difficulty concentrating, remembering, or making decisions? |
nih_walk_climb | Do you have serious difficulty walking or climbing stairs? |
nih_dress_bathe | Do you have difficulty dressing or bathing? |
nih_errand | Because of a physical, mental, or emotional condition, do you have difficulty doing errands alone such as visiting a doctor's office or shopping? |
nih_vape_freq | Vaping Frequency: Do you now use electronic cigarettes every day, some days, rarely, or not at all? |
nih_cig_smoke_freq | Nicotine Frequency: Do you now smoke cigarettes? |
nih_smoking_yn | Do you use any tobacco/nicotine products (including cigarettes, cigars, e-cigarettes, etc)? |
nih_alcohol_yrs | How often did you have a drink containing alcohol in the past year? |
nih_asthma | Asthma |
nih_cancer | Cancer |
nih_cancer_active_treatment | Cancer (including leukemia or lymphoma) undergoing active treatment? |
nih_cardiovascular_disease | Cardiovascular disease |
nih_chronic_kidney_disease | Chronic kidney disease |
nih_diabetes | Diabetes |
nih_hypertension | Hypertension |
nih_mental_health_disorder | Mental health disorder |
nih_sickle_cell_disease | Sickle cell disease |
nih_pregnancy | Pregnancy status |
nih_immunocompromised | Immunocompromised condition |
nih_chronic_lung | Other chronic lung disease |
nih_depression | Depression |
nih_alc_sub_abuse | Alcohol or substance use disorder |
nih_iv_drug_use | Intravenous drug use |
nih_othermh | Other mental health disorder |
nih_heart_attack | A heart attack (myocardial infarction)? |
nih_chf | Congestive Heart failure (CHF, Heart Failure)? |
nih_stroke | Stroke or TIA (Transient Ischemic Attack or Mini-Stroke)? |
nih_immunodeficiency | Immunodeficiency (NOT including HIV)? |
nih_hiv | Chronic HIV infection? |
nih_anemia | Anemia or other blood disorder (do not include leukemia or lymphoma)? |
nih_premature_birth | History of premature birth (being born before 37 weeks of pregnancy) |
nih_chd | Chronic Heart Disease |
nih_cf | Cystic Fibrosis |
nih_cld_bpd | CLD BPD (Chronic Lung Disease Bronchopulmonary Dysplasia) |
nih_copd_plus | Chronic obstructive pulmonary disease (COPD) including emphysema, chronic bronchitis, obstructive pulmonary disease? |
nih_no_chronic_condition | No chronic condition |
nih_cough | Cough |
nih_fever_chills | Fever or Chills |
nih_diff_breath | Shortness of breath or difficulty breathing |
nih_headache | Headache |
nih_muscle_ache | Muscle ache |
nih_olfactory | New loss of taste or smell |
nih_fatigue | Excessive fatigue |
nih_nausea_vomiting_diarrhea | Nausea, vomiting, or diarrhea |
nih_abdom_pain | Abdominal pain |
nih_skin_rash | Skin rash |
nih_throat_congestion_nose | Sore throat, congestion or runny nose |
nih_red_eyes | Red or painful eyes |
nih_high_temp | A temperature greater than 100.4 °F |
nih_other_symp | Other |
nih_no_sympt | None of the above |
nih_height | What is your height in inches? |
nih_weight | What is your weight in pounds? |
nih_height_category | Approximately what is your height? |
nih_weight_category | Approximately what is your weight? |
anemia | Anemia or other blood disorder (do not include leukemia or lymphoma)? |
asthma | Asthma, to the point that you use inhalers daily or have been to the hospital for your asthma? |
cancer | Cancer (including leukemia or lymphoma) undergoing active treatment? |
chf | Congestive Heart failure (CHF, Heart Failure)? |
copd | COPD (emphysema, chronic bronchitis, obstructive pulmonary disease)? |
diabetes | Diabetes? Do not include pre-diabetes. |
immunodeficiency | Immunodeficiency (NOT including HIV)? |
stroke | Stroke or TIA (Transient Ischemic Attack or Mini-Stroke)? |
user_id | User ID |
age | - |
alcohol_past_yr | - |
assistance | - |
chronic_hiv_inf | - |
collection_day | - |
confide | - |
coronary_disease | - |
day0_to_sx | - |
education | - |
gender_identity__1 | - |
gender_identity__2 | - |
gender_identity__3 | - |
gender_identity__4 | - |
gender_identity__5 | - |
gender_identity_addl_options | - |
gender_identity_specify | - |
guests | - |
height | - |
high_bp | - |
hispanic__1 | - |
hispanic__2 | - |
hispanic__3 | - |
hispanic__4 | - |
hispanic__5 | - |
housing | - |
interact | - |
kidney_failure | - |
mi | - |
nasal_swab_antigen | - |
nasal_swab_ct_1 | - |
nasal_swab_ct_2 | - |
nasal_swab_instrument | - |
nasal_swab_result | - |
nih_chronic_kidney_disease_treat | - |
nih_coronary_artery_disease_angi | - |
nih_studyday | - |
numb_close_relatives | - |
pushing | - |
quarantine_challenges__1 | - |
quarantine_challenges__10 | - |
quarantine_challenges__11 | - |
quarantine_challenges__12 | - |
quarantine_challenges__2 | - |
quarantine_challenges__3 | - |
quarantine_challenges__4 | - |
quarantine_challenges__5 | - |
quarantine_challenges__6 | - |
quarantine_challenges__7 | - |
quarantine_challenges__8 | - |
quarantine_challenges__9 | - |
quess_exposed | - |
race__1 | - |
race__2 | - |
race__3 | - |
race__4 | - |
race__5 | - |
race__6 | - |
race__7 | - |
redcap_data_access_group | - |
saliva_ct_ms | - |
saliva_ct_n | - |
saliva_ct_orf1 | - |
saliva_ct_s | - |
saliva_result | - |
sickle_cell | - |
sitting_2hrs | - |
standing_2hrs | - |
standing_from_chair | - |
sx_past_48hrs__1 | - |
sx_past_48hrs__10 | - |
sx_past_48hrs__11 | - |
sx_past_48hrs__12 | - |
sx_past_48hrs__2 | - |
sx_past_48hrs__3 | - |
sx_past_48hrs__4 | - |
sx_past_48hrs__5 | - |
sx_past_48hrs__6 | - |
sx_past_48hrs__7 | - |
sx_past_48hrs__8 | - |
sx_past_48hrs__9 | - |
walk_10steps | - |
walk_2blocks | - |
walk_btwn_rooms | - |
weight | - |
why_quarantining | - |