dbGaP Study Accession: phs002608

NIH Institute/Center: NIDA

RADx Data Program: RADx-UP

Release Date: 12/07/2023

DOI: 10.60773/sh92-7q42

Updated Date: 04/17/2024

Study Description: Racial minorities have disproportionate risk for SARS-CoV-2 diagnoses and adverse outcomes including death. Burden of disease in Black populations is likely underestimated due to sub-optimal access to, and usage of, SARS-CoV-2 testing. Serosurveys, which use probability-based methods to select persons for SARS-CoV-2 testing and an accompanying survey, have potential to improve understanding of population-level burden of disease and risk factors for infection. However, early results from U.S.-based serosurveys indicate sub-optimal participation rates among Black populations, which results in their under-representation in burden of disease estimates and a limited understanding of risk factors for infection. The current project aimed to identify barriers and motivations for participation in population-based SARS-CoV-2 serosurveys among diverse Black sub-populations (e.g., by gender, age, and education level). Understanding factors that influence Black people's decision-making about serosurvey participation and how these factors differ by socio-demographic characteristics enabled tailored recommendations for increasing Black populations' participation in serosurveys and representation in burden of disease estimates. The interdisciplinary team of epidemiologists, behavioral scientists, and community health advocates/practitioners used qualitative and quantitative methods in the context of serosurveys to understand how influences on decision-making are related to actual decisions about participation in SARS-CoV-2 antibody testing. The qualitative interview guide was informed by the family of value expectancy theories and was developed in collaboration with a community advisory board (CAB), who also helped to identify community constituents for participation in qualitative interviews. Key themes from the qualitative interviews, and language used by respondents, informed a quantitative survey instrument, which assessed relative strengths of influences on serosurvey participation and how they differ socio-demographically across Black sub-populations. The Specific Aims of this study were: (1) Convene a community advisory board (CAB) comprising leaders from organizations serving Black communities in Atlanta (e.g., professional, faith-based, health and social services); (2) In the context of a SARS-CoV-2 serosurvey, conduct 50 semi-structured interviews about barriers and motivations for serosurvey and vaccine participation with Black persons from 3 diverse neighborhoods, representing a range of socio-demographic characteristics; (3) Determine the distribution of barriers and motivations for serosurvey participation across socio-demographic subgroups of 2,000 Black persons using a quantitative survey. Recommendations for increasing participation of black communities in SARS-CoV-2 serosurveys were provided, which is critical as SARS-CoV-2 serosurveys were likely to be used for on-going disease surveillance in the U.S. and to inform both resource allocation and design and monitoring of prevention and control strategies.

Principal Investigator: Bradley, Heather

Has Data Files: Yes

Study Domain: Pandemic Perceptions and Decision-Making; Social Determinants of Health; Serological (Antibody) Testing; Testing Rate/Uptake

Data Collection Method: Survey; Interview or Focus Group

Keywords: Testing Disparities; Serosurveys

Study Design: Mixed Methods

Multi-Center Study: FALSE

Data Types: Behavioral; Questionnaires/Surveys; Clinical

Study Start Date: 12/01/2020

Study End Date: 11/30/2022

Species: Human Data

Estimated Cohort Size: 2050

Study Population Focus: African American; Older Adults or Elderly; Adults; Children

Acknowledgement Statement: This study was supported through funding, 3R01DA051302-01S1, for the National Institute on Drug Abuse (NIDA) as part of the RADx-UP program. Approved users should acknowledge the provision of data access by dbGaP for accession phs002608.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.

Funding Opportunity Announcement (FOA) Number: PA-20-135

NIH Grant or Contract Number(s): 3R01DA051302-01S1

Consent/Data Use Limitations: General Research Use