dbGaP Study Accession: phs002920

NIH Institute/Center: NLM

RADx Data Program: RADx-UP

DOI: 10.60773/ksgc-r355

Release Date: 08/29/2023

Study Description: African American and Latinx communities nationally and in California not only bear a disproportionate burden of COVID-19 positive cases and deaths but are also not taking part in COVID-19 testing for a wide range of understudied reasons. This can have profound implications in safety net health care settings that care for the most vulnerable patients. The Los Angeles County Department of Health Services (LACDHS) is the second largest publicly operated county safety net health care system in the United States, serving more than 750,000 patients annually. Timely access to health care in this under-resourced, high-need setting has been an ongoing challenge for its majority Latinx and African American patients. With the current pandemic, COVID-19 testing for patients has become integral to receiving critical health care, from treatment for symptomatic disease to the first step in providing procedural care. However, the range of reasons why patients refuse COVID-19 testing and vaccinations is little understood. To this end, the study proposed to explore the obstacles to COVID-19 testing and vaccinations to provide COVID-19 specific training to LACDHS Community Health Workers (CHWs) from these same communities to effectively address: a) the primary goal of increasing COVID-19 testing and vaccinations for individual patients, and b) developing a sustained public health presence in these communities to build trust and preparedness for critical COVID-19 related future needs. Trained CHWs can help to more effectively overcome obstacles to COVID-19 testing and vaccinations, including historical barriers of mistrust, provide COVID-19 health education, help address social determinants of health and help facilitate technological literacy to improve patient access to testing and care in a telehealth environment. The proposal used a multidisciplinary, mixed-methods approach including unsupervised machine learning and qualitative interviews to systematically explore barriers and facilitators to COVID-19 testing/vaccinations among vulnerable safety net patients. The study then trained clinically-based, ethnically/linguistically matched CHWs to implement a hypothesis-driven intervention consisting of six group classes and six personalized patient encounters with African American and Latinx safety net patients. This study had the following specific aims: Aim 1- Utilize machine learning methods to assess whether there are characteristics that define two sets of African American and Latinx safety net patients, a) those who engage in or refuse COVID-19 testing and b) those who engage in or refuse COVID-19 vaccinations; Aim 2 - Conduct in-depth interviews with African American and Latinx patients who either declined or accepted COVID-19 testing and/or vaccinations to explore contextual, behavioral, and attitudinal factors shaping patient circumstances and concerns; Aim 3 - Develop, implement, and pre-test a CHW intervention with the information from Aims 1 and 2, utilizing a randomized control design among African American and Latinx safety net patients to assess the effect of the CHW hypothesis-driven intervention on trust, self-efficacy, and intent to participate in COVID-19 testing/ re-testing and vaccinations.

Updated Date: 04/17/2024

Principal Investigator: Ogunyemi, Omolola I

Has Data Files: Yes

Study Domain: Pandemic Perceptions or Decision-Making; Testing Rate or Uptake; Vaccination Rate or Uptake; Virological Testing

Data Collection Method: Interview or Focus Group; Survey

Keywords: Building Trust Amongst Marginalized Communities

Study Design: Interventional or Clinical Trial

Multi-Center Study: Yes

Study Sites: Charles R. Drew University of Medicine and Science; Los Angeles County Department of Health Services

Data Types: Behavioral; Electronic Medical Records; Questionnaire or Survey

Study Start Date: 09/09/2020

Study End Date: 11/30/2022

Species: Human

Estimated Cohort Size: 128

Study Population Focus: Adults; African Americans; Hispanics or Latinos; Older Adults or Elderly; Racial or Ethnic Minorities; Underserved or Vulnerable Populations

Acknowledgement Statement: This study was supported through funding, 3R01LM012309-04S2, for the National Library of Medicine (NLM) as part of the RADx-UP program. We acknowledge the support of project staff, community health workers and study participants from the Los Angeles County Department of Health Services in acquiring these data. Approved users should acknowledge the provision of data access by dbGaP for accession phs002920.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.

Funding Opportunity Announcement (FOA) Number: PA-13-302

NIH Grant or Contract Number(s): 3R01LM012309-04S2

Consent/Data Use Limitations: General Research Use