dbGaP Study Accession: phs002791

NIH Institute/Center: NIEHS

RADx Data Program: RADx-UP

Release Date: 08/30/2023

DOI: 10.60773/86zb-bq66

Updated Date: 04/17/2024

Study Description: The COVID-19 pandemic has disproportionately affected the already underserved Latinx communities. The overall goal of the testing research project was to decrease disparities in the morbidity and mortality patterns for COVID-19 through engaged partnerships with several communities in central California that are both historically underserved and vulnerable to COVID-19, namely the Latinx. These communities currently are experiencing infection rates that are three times higher than whites, and are among the highest in the U.S. They also are among the most socially and economically disadvantaged, have high rates of co-morbidities such as diabetes and asthma, live in overcrowded housing, and reside in some of the most polluted areas of the country. A high proportion are undocumented and employed in food production, especially farm labor, performing essential work that has been a backbone of the California economy, while simultaneously being marginalized. This research built upon long-term existing partnerships with an array of community-based organizations and trusted leaders in Latinx communities to develop interventions that address the barriers to SARS-CoV2 diagnostics, as part of a larger strategy to reduce transmission and control the pandemic in the Latinx population of central California. Because of the dynamic changes in incidence, shifting hubs of transmission, and policy changes from authorities, a comparator trial of different community- developed interventions was needed to provide information on which actions are feasible, acceptable, and effective. Hence, comparisons were made between the Latinx population and whites in the same counties, and among Latinx persons from counties having different interventions, with adjustment for infection incidence rates and trajectories, as well as local policy changes and government interventions. This study pursued the overall goal with the following specific aims: 1) Determine the epidemiology of COVID-19 infections, COVID-19 related mortality, and SARS-CoV-2 testing rates in selected Latinx and white non-Latinx communities of targeted California counties, 2) Develop strategies to increase testing and reduce rates of infection in the targeted areas in collaboration with community partners and, 3) Disseminate information and knowledge gained from this project back to partnering communities, other grantees from this and other COVID-19 initiatives by full participation in RADx-UP Coordinating Data and Collection Center (CDCC), to the broad public, and to policy- makers. Experience and knowledge gained through achievement of these aims set a firm foundation for subsequent research on COVID-19 and health disparities and helped to prepare communities to meet the challenges of future public health crises.

Principal Investigator: Hertz-Picciotto, Irva

Has Data Files: Yes

Study Domain: Comorbidities; Testing Rate/Uptake; Community Outreach Programs; Mobile Unit Testing

Data Collection Method: Survey

Keywords: Individual-Level Data; Asthma; Diabetes; Diabetes Patients; Asthma Patients; Congregate Settings; COVID-19 Morbidity Rates; COVID-19 Mortality Rates; COVID Epidemiology; COVID Incidence; Infection Rates

Study Design: Longitudinal Cohort

Multi-Center Study: FALSE

Data Types: Clinical; Questionnaires/Surveys; Individual Phenotype

Study Start Date: 09/24/2020

Study End Date: 03/31/2022

Species: Human Data

Estimated Cohort Size: 22000

Study Population Focus: Lower Socioeconomic Status (SES) Population; Older Adults or Elderly; Essential Workers; Children; Adults; Hispanic and Latino

Acknowledgement Statement: This study was supported through funding, 3P30ES023513-07S2, for the National Institute of Environmental Health Sciences (NIEHS) as part of the RADx-UP program. Approved users should acknowledge the provision of data access by dbGaP for accession phs002791.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.

Funding Opportunity Announcement (FOA) Number: PA-20-135

NIH Grant or Contract Number(s): 3P30ES023513-07S2

Consent/Data Use Limitations: General Research Use