dbGaP Study Accession: phs002742

NIH Institute/Center: NIGMS

RADx Data Program: RADx-UP

Release Date: 08/30/2023

DOI: 10.60773/bxqp-9045

Study Description: Non-Native Hawaiian Pacific Islanders (PI), defined as indigenous people having origins in Guam, the Commonwealth of the Northern Mariana Islands, American Samoa, Federated States of Micronesia, Republic of the Marshall Islands and Republic of Palau, have among the highest COVID-19-associated morbidity and mortality rates in the U.S. PI also suffer from medical co-morbidities known to increase their risk of severe COVID-19. In addition, PI have poor access to health care, inadequate or no health insurance, live in multi-generational or multi-family overcrowded housing, and have low-paying service jobs that expose them to the infected public. In Hawaii, PI comprise only 4% of the State's population but account for more than 20% of COVID-19 cases and deaths. The long-term goal was to reduce COVID-19 disparities among PI. The overall objective was to use culturally resonant community-engagement strategies to increase the reach and uptake of COVID-19 testing to better understand SARS-CoV-2 infection patterns among PI in Hawaii and on Guam. The multi-disciplinary investigative team comprises of physicians and community health workers, community-engaged researchers and basic and applied scientists. Strong support from the institution, community, and local government attest to the urgency of this RADx-UP Community-Engagement Testing Research Project.

Updated Date: 04/17/2024

Principal Investigator: Yanagihara, Richard

Has Data Files: Yes

Study Domain: Virological Testing; Testing Rate/Uptake; Rapid Diagnostic Test (RDT); Community Outreach Programs

Data Collection Method: Antigen Testing Device; Survey

Study Design: Interventional/Clinical Trial

Multi-Center Study: TRUE

Study Sites: University of Hawaii at Manoa and University of Guam

Data Types: Questionnaires/Surveys; Behavioral

Study Start Date: 11/01/2020

Study End Date: 10/31/2022

Species: Human Data

Estimated Cohort Size: 4800

Study Population Focus: Native Hawaiian or other Pacific Islander; Adults

Study Website URL: https://radx-up.org/project-spotlight/pupipuia-le-ola/#:~:text=March%201%2C%202021-,Pupipuia%20le%20Ola%3A%20Increasing%20Reach%20and%20Uptake%20of%20COVID%2D19,Islanders%20in%20Hawaii%20and%20Guam&text=The%20University%20of%20Hawaii%20at,infection%20patterns%20in%20those%20communities.

Publication URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341953/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745036/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143625/

Acknowledgement Statement: This study was supported through funding, 3P30GM114737-05S1, for the National Institute of General Medical Sciences (NIGMS) as part of the RADx-UP program. We thank study staff and study participants from the CHamoru, Chuukese, Kosraean, Marshallese, Pohnpeian, Samoan, and Yapese communities. We also the Dean of the John A. Burns School of Medicine for institutional support. Finally, we thank Quidel for providing rapid antigen tests (QuickVue SARS POC Test and QuickVue At-Home OTC Test) to broaden testing options for our hard-to-reach target communities. Approved users should acknowledge the provision of data access by dbGaP for accession phs002742.v1.p1, and the NIH RADx Data Hub. Approved users should also acknowledge the specific version(s) of the dataset(s) obtained from the NIH RADx Data Hub.

Funding Opportunity Announcement (FOA) Number: PA-20-135

NIH Grant or Contract Number(s): 3P30GM114737-05S1

Consent/Data Use Limitations: General Research Use